Formulasi tablet hisap ekstrak etanol daun kemangi (Ocimum sanctum L.) dengan variasi konsentrasi bahan pengikat gelatin

Basil leaves (Ocimum sanctum L.) contain secondary metabolites as inhibitors of the growth pathogenic microbes in mouth, so they can be used lozenges. The choice binder formulation is very important, because it affect physical properties tablet. purpose this study was to determine content basil leaf extract and best formula for lozenges ethanol based on variations gelatin binding agents. were extracted using sonication method with 96% solvent subjected phytochemical screening (test tube TLC). Tablets formulated wet granulation 1 (5%), 2 (7.5%), 3 (10%). granules are evaluated compressed. resulting tablets properties. results showed that contained compounds belonging class flavonoids, saponins tannins. granule flow time test did not meet requirements, met requirements Indonesian Pharmacopoeia Edition III. angle repose, settling, water tests (formula 1, 2, 3) tablet evaluation weight uniformity formulas 257 mg ± 0.226; 248 0.068 253 0.157. Tablet hardness 3.721 kg 0.268; 4.221 0.929 6.636 1.035. friability 3.4% 0.152; 1.1% 0.264 0.9% 0.1. disintegration 7.6 minutes 2.452; 11 2.154 18.6 4.016. From concluded has Variations tablet, where concentration